2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Phycocyanobilin

Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

Phycocyanobilin Chemical Structure

Phycocyanobilin Chemical Structure

CAS No. : 20298-86-6

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Customer Review

Based on 1 publication(s) in Google Scholar

Phycocyanobilin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease[1][2][3].

In Vitro

Phycocyanobilin (100 μM; 0-250 min) inhibits the peroxidation of methyl linoleate and produces a prolonged induction period[1].
Phycocyanobilin (1 mM; 0-300 min) suppresses the oxidation of the liposomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phycocyanobilin Related Antibodies
In Vivo

Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) shows antioxidant effects in type 2 diabetes mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes[3]
Dosage: 15 mg/kg
Administration: In diet for 2 weeks
Result: Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1.
Molecular Weight

586.68

Formula

C33H38N4O6
CAS No.
Appearance

Solid

Color

Blue to dark blue

SMILES

O=C(NC/1=C\C2=C(C)C(CCC(O)=O)=C(/C=C3C(CCC(O)=O)=C(C(/C=C(C(C)=C4CC)\NC4=O)=N/3)C)N2)[C@H](C)C1=C\C
Structure Classification
Initial Source

Spirulina platensis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (10.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7045 mL 8.5225 mL 17.0451 mL
5 mM 0.3409 mL 1.7045 mL 3.4090 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (17.05 mM); Suspended solution; Need ultrasonic

  • Protocol 2

    Add each solvent one by one:  Tris-HCL Buffer

    Solubility: 5.88 mg/mL (10.02 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.90%

COA (257 KB) HNMR (508 KB) RP-HPLC (270 KB) LCMS (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7045 mL 8.5225 mL 17.0451 mL 42.6127 mL
5 mM 0.3409 mL 1.7045 mL 3.4090 mL 8.5225 mL
10 mM 0.1705 mL 0.8523 mL 1.7045 mL 4.2613 mL
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Phycocyanobilin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phycocyanobilin20298-86-6Reactive Oxygen Speciesantioxidanttype 2 diabetesAlzheimer’s diseaseNAD(P)Hsuperoxide productionInhibitorinhibitorinhibit

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