2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Akt mTOR Apoptosis
  4. PI3K/Akt/mTOR-IN-3

PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC50 values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest.

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PI3K/Akt/mTOR-IN-3 Chemical Structure

PI3K/Akt/mTOR-IN-3 Chemical Structure

CAS No. : 2457245-94-0

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PI3K/Akt/mTOR-IN-3 Related Antibodies

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Description

PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC50 values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest[1].

Molecular Weight

505.77

Formula

C34H51NO2
CAS No.
SMILES

CC1(C)C(C(C[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(NCC=C)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=C)=O
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References
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PI3K/Akt/mTOR-IN-3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/Akt/mTOR-IN-32457245-94-0PI3KAktmTORApoptosisPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinMCF-7HepG2HeLaoleanolic acid derivativesAnticancerPI3K/AKT/mTOR signaling pathwayCell apoptosis inductionS phase arrestInhibitorinhibitorinhibit

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