2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K-IN-22

PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer.

For research use only. We do not sell to patients.

PI3K-IN-22 Chemical Structure

PI3K-IN-22 Chemical Structure

CAS No. : 1202884-94-3

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Based on 1 publication(s) in Google Scholar

PI3K-IN-22 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer[1].

IC50 & Target[1]

PI3Kα

0.9 nM (IC50)

mTOR

0.6 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
MDA-MB-361 IC50
< 3 nM
Compound: 46
Cytotoxicity against human MDA-MB-361 cells with Her2+/PI3KCA mutant after 72 hrs
Cytotoxicity against human MDA-MB-361 cells with Her2+/PI3KCA mutant after 72 hrs
[PMID: 20334367]
PC-3 IC50
13 nM
Compound: 46
Cytotoxicity against human PC3 cells with PTEN mutant after 72 hrs
Cytotoxicity against human PC3 cells with PTEN mutant after 72 hrs
[PMID: 20334367]
In Vitro

PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of <3.0 and 13.0 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-22 Related Antibodies
In Vivo

PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in MDA361 tumor bearing nude mice demonstrated by biomarker studies[1].
PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) shows good antitumor efficacy in MDA361 tumor xenograft nude mice model[1].
PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA361 tumor xenograft nude mice model[1]
Dosage: 50, 25, 10 mg/kg
Administration: i.v., once daily for 5 days weekly (2 rounds)
Result: Exhibited significant tumor regression in 50 mg/kg and no tumor regrowth until day 32.
Exhibited tumor growth inhibition in 25 and 10 mg/kg.
Molecular Weight

624.66

Formula

C31H35F3N8O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC1=CC=C(C(N(C)CCN(C)C)=O)C=C1)NC(C=C2)=CC=C2C3=NC4=C(C=CN4CC(F)(F)F)C(N5CCOCC5)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 15 mg/mL (24.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6009 mL 8.0044 mL 16.0087 mL
5 mM 0.3202 mL 1.6009 mL 3.2017 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.50%

SDS (252 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6009 mL 8.0044 mL 16.0087 mL 40.0218 mL
5 mM 0.3202 mL 1.6009 mL 3.2017 mL 8.0044 mL
10 mM 0.1601 mL 0.8004 mL 1.6009 mL 4.0022 mL
15 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6681 mL
20 mM 0.0800 mL 0.4002 mL 0.8004 mL 2.0011 mL
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PI3K-IN-22 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-221202884-94-3PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinnude micetumorMDA361PC3cellscell growthratInhibitorinhibitorinhibit

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