PI3K-IN-29

Cat. No.: HY-144450: FAQs
Data Sheet Handling Instructions

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PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀ values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K.

For research use only. We do not sell to patients.

PI3K-IN-29 Chemical Structure

CAS No. : 2768005-77-0

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

PI3K-IN-29 (compound 25) (72 h) displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀ values of 0.264, 2.04 and 1.14 µM, respectively^[1].
PI3K-IN-29 (U87MG cells; 1, 5 µM; 1 h) inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	U87MG, HeLa, HepG2, A549, HL60, MCF7 cells
Concentration:
Incubation Time:	72 h
Result:	Displayed good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀ values of 0.264, 2.04 and 1.14 µM, respectively.

Western Blot Analysis^[1]

Cell Line:	U87MG cells
Concentration:	1, 5 µM
Incubation Time:	1 h
Result:	Inhibited PI3K/Akt pathway by inhibiting phosphorylation of Akt that was catalyzed by PI3K.

Molecular Weight

560.03

Formula

C₂₇H₂₂ClN₇O₃S

CAS No.

2768005-77-0

SMILES

O=S(NC1=CC(C2=CC=C3N=NC=C(C3=C2)C4=CN=C(N=C4)N5CCOCC5)=CN=C1Cl)(C6=CC=CC=C6)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tian C, et al. Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2021, 48:128271. [Content Brief]

PI3K-IN-29 Related Classifications

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-292768005-77-0PI3KAktPhosphoinositide 3-kinasePKBProtein kinase Bantiproliferativecinnoline derivativesPI3K/AktphosphorylationU87MG cellsInhibitorinhibitorinhibit

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