2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K-IN-37

PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM).

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PI3K-IN-37 Chemical Structure

PI3K-IN-37 Chemical Structure

CAS No. : 1257547-40-2

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Based on 1 publication(s) in Google Scholar

PI3K-IN-37 Related Antibodies

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Description

PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM)[1].

IC50 & Target[1]

PI3Kδ

4 nM (IC50)

mTOR

4 nM (IC50)

PI3Kα

6 nM (IC50)

PI3Kβ

8 nM (IC50)

In Vitro

PI3K-IN-37 (0.005-10 μM; 30 min) treatment inhibits PKB Ser473 phosphorylation in Rat1 cells[1].
PI3K-IN-37 (0.005-1 μM; 60 min) treatment inhibits S6 Ribosomal Protein phosphorylation Ser235/236 in TSC1 nult MEF cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-37 Related Antibodies

Cell Viability Assay[1]

Cell Line: Rat1 cells
Concentration: 0.005-10 μM
Incubation Time: 30 min
Result: Inhibited Pl3-kinase isoforms alpha, beta or delta phosphorylation with the IC50s of <5 nM, 8 nM, and 18 nM, respectively.

Cell Viability Assay[1]

Cell Line: TSC1-/- MEF cells
Concentration: 0.005-1 μM
Incubation Time: 60 min
Result: Inhibited S6 Ribosomal Protein phosphorylation (IC50=2 nM).
Molecular Weight

442.51

Formula

C25H26N6O2
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C1N(C2=C(N1C)C=NC3=CC=C(C4=CC(OC(C)C)=C(C)N=C4)C=C23)C5=CN(C)N=C5C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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PI3K-IN-37 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-371257547-40-2PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinRat1TSC1-/- MEFInhibitorinhibitorinhibit

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