2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Apoptosis
  4. PI3K-IN-55

PI3K-IN-55 (Compound 6a) is a potent inhibitor for PI3K. PI3K-IN-55 affects PI3K/Akt/p53 signaling pathway, inhibits the proliferation of cancer cells A549, Hela, HepG2, MCF-7 and HT-29, with IC50s of 1.03-6.78 μM. PI3K-IN-55 induces apoptosis in cell MCF-7.

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PI3K-IN-55 Chemical Structure

PI3K-IN-55 Chemical Structure

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PI3K-IN-55 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

PI3K-IN-55 (Compound 6a) is a potent inhibitor for PI3K. PI3K-IN-55 affects PI3K/Akt/p53 signaling pathway, inhibits the proliferation of cancer cells A549, Hela, HepG2, MCF-7 and HT-29, with IC50s of 1.03-6.78 μM. PI3K-IN-55 induces apoptosis in cell MCF-7[1].

Molecular Weight

640.61

Formula

C30H28N2O12S
SMILES

O=C(/C(C(/C=C/C1=CC=C(OCCO[N+]([O-])=O)C(OC)=C1)=O)=C/C2=CC=CS2)/C=C/C3=CC(OC)=C(OCCO[N+]([O-])=O)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K-IN-55 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-55PI3KApoptosisPhosphoinositide 3-kinaseA549HelaHepG2MCF-7HT-29LO-2HK-2breast cancerInhibitorinhibitorinhibit

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