2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3K-IN-9

PI3K-IN-9 (compound 1-14) is a potent and selective PI3Kδ inhibitor with an IC50 of 8.9 nM.

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PI3K-IN-9 Chemical Structure

PI3K-IN-9 Chemical Structure

CAS No. : 2360875-63-2

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PI3K-IN-9 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

PI3K-IN-9 (compound 1-14) is a potent and selective PI3Kδ inhibitor with an IC50 of 8.9 nM[1].

IC50 & Target[1]

PI3Kδ

 

Cellular Effect
Cell Line Type Value Description References
Sf21 IC50
9 nM
Compound: 29
Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr
Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr
[PMID: 31757666]
Molecular Weight

365.43

Formula

C19H23N7O
CAS No.
SMILES

O=C([C@@H]1C[C@H]1C)N(CC2)[C@H](C)CN2C3=CN=C(C#N)C(C4=CN(C)N=C4)=N3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-92360875-63-2PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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