2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K/mTOR Inhibitor-12

PI3K/mTOR Inhibitor-12 is a potent, orally active and selective PI3K/mTOR inhibitor with IC50 values of 0.06 nM and 3.12 nM for PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-12 has antitumor activity. PI3K/mTOR Inhibitor-12 has lower liver toxicity.

For research use only. We do not sell to patients.

PI3K/mTOR Inhibitor-12 Chemical Structure

PI3K/mTOR Inhibitor-12 Chemical Structure

CAS No. : 2891692-83-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PI3K/mTOR Inhibitor-12 Related Antibodies

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

View All mTOR Isoform Specific Products:

View All Isoforms
mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PI3K/mTOR Inhibitor-12 is a potent, orally active and selective PI3K/mTOR inhibitor with IC50 values of 0.06 nM and 3.12 nM for PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-12 has antitumor activity. PI3K/mTOR Inhibitor-12 has lower liver toxicity[1].

IC50 & Target[1]

PI3Kα

0.06 nM (IC50)

mTOR

3.12 nM (IC50)

In Vitro

PI3K/mTOR Inhibitor-12 (compound 48; 72 h) inhibits cancer cells growth with IC50 values of 0.07, 0.09, 0.54, 0.54, and 0.68 μM for PC-3, HT-29,HCT116, LOVO, and HUVEC cells, respectively[1].
PI3K/mTOR Inhibitor-12 (0.25-1 μM; 12-48 h; HCT116 and HT-29 cells) inhibits the activation of PI3K and mTOR in the cellular context[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/mTOR Inhibitor-12 Related Antibodies

Western Blot Analysis[1]

Cell Line: HCT116 and HT-29 cells
Concentration: 0.25, 0.5, and 1 μM
Incubation Time: 12, 24, and 48 hours
Result: Inhibited the expression levels of AKT, p70S6K and their phosphorylated forms in a dose- and time-dependent manner.
In Vivo

PI3K/mTOR Inhibitor-12 (compound 48; 20 mg/kg; p.o.; daily, for 14 d) inhibits tumor growth of HCT116 xenografts in female BALB/c nude mice[1].
PI3K/mTOR Inhibitor-12 (1 and 5 mg/kg; i.v. and p.o.; male SD rats) has fast plasma clearance (1428 mL/h/kg) and short T1/2 (2.33 h) and the AUC0-∞ is 1356 h*ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT116 xenografts in female BALB/c nude mice[1]
Dosage: 20 mg/kg
Administration: Oral administration, daily, for 14 days
Result: Reduced the growth of HCT116 tumors, and the tumor growth inhibition (TGI) was 73.33%.
Had lower liver toxicity of HCT116 xenografts in female BALB/c nude mice.
Animal Model: Male SD rats[1]
Dosage: 1 and 5 mg/kg
Administration: Intravenous injection (1 mg/kg) and oral administration (5 mg/kg)
Result: 1.19
Parameter I.V. (1 mg/kg) Parameter P.O. (5 mg/kg)
T1/2 (h) 0.6 T1/2 (h) 2.33
CL (mL/h/kg) 1428 Cmax (ng/mL) 1218
Vdss (mL/Kg) 528 AUC0-∞ (h*ng/mL) 1356
AUC0-∞ (h*ng/mL) 760 F% 33.1
Molecular Weight

611.62

Formula

C27H27F2N9O4S
CAS No.
SMILES

O=S(C1=CC=C(F)C=C1F)(NC2=CC(C3=NN4C(C=C3)=NC=C4C5=CN(CCCN6CCOCC6)N=N5)=CN=C2OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PI3K/mTOR Inhibitor-12 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-122891692-83-2PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinanticancerliver toxicityHCT116HT-29phosphorylationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PI3K/mTOR Inhibitor-12
Cat. No.:
HY-152238
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.