2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K/mTOR Inhibitor-6

PI3K/mTOR Inhibitor-6 (Compound 19c) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-6 displays better stability in artificial gastric fluids than gedatolisib. PI3K/mTOR Inhibitor-6 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-6 has the potential for the research of cancer diseases.

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PI3K/mTOR Inhibitor-6 Chemical Structure

PI3K/mTOR Inhibitor-6 Chemical Structure

CAS No. : 2456295-59-1

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PI3K/mTOR Inhibitor-6 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

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Description

PI3K/mTOR Inhibitor-6 (Compound 19c) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-6 displays better stability in artificial gastric fluids than gedatolisib. PI3K/mTOR Inhibitor-6 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-6 has the potential for the research of cancer diseases[1].

Cellular Effect
Cell Line Type Value Description References
CNE-2 IC50
7.3 μM
Compound: 19c
Antiproliferative activity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HCT-116 IC50
0.9 μM
Compound: 19c
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HeLa IC50
7.7 μM
Compound: 19c
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
HepG2 IC50
23 μM
Compound: 19c
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
MCF7 IC50
0.3 μM
Compound: 19c
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
MDA-MB-231 IC50
5.5 μM
Compound: 19c
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32717477]
Molecular Weight

598.66

Formula

C30H34N10O4
CAS No.
SMILES

O=C([C@@H]1N(C(C2=CC=C3C(NC(NC4=CC=C(C5=NC(N6CCOCC6)=NC(N7CCOCC7)=N5)C=C4)=N3)=C2)=O)CCC1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K/mTOR Inhibitor-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-62456295-59-1PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinartificial gastric fluidsgedatolisibcancerInhibitorinhibitorinhibit

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