2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kα-IN-22

PI3Kα-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3KαH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kα-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice.

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PI3Kα-IN-22 Chemical Structure

PI3Kα-IN-22 Chemical Structure

CAS No. : 2925030-26-6

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Description

PI3Kα-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3KαH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kα-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice[1].

Molecular Weight

467.47

Formula

C24H23F2N5O3
CAS No.
SMILES

CC(C=C([C@H](NC1=CC=CC=C1C(O)=O)C)C2=NC(N3CCC(F)(F)CC3)=C4C#N)=CN2C4=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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PI3Kα-IN-22 Related Classifications

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Keywords:

PI3Kα-IN-222925030-26-6PI3KPhosphoinositide 3-kinasetumor regressionspAKTT47DAlphaLISAorally activeHCC1954Inhibitorinhibitorinhibit

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