PI3Kα-IN-24

Cat. No.: HY-116563: FAQs
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PI3Kα-IN-24 (WR23) is a PI3Kα inhibitor with an IC₅₀ of 0.025 μM and exhibits a significant pAkt^Ser473 suppression effect. PI3Kα-IN-24 can be utilized in cancer research.

For research use only. We do not sell to patients.

PI3Kα-IN-24 Chemical Structure

CAS No. : 1350960-66-5

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Biological Activity
Purity & Documentation
References
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Description

PI3Kα-IN-24 (WR23) is a PI3Kα inhibitor with an IC₅₀ of 0.025 μM and exhibits a significant pAkt^Ser473 suppression effect. PI3Kα-IN-24 can be utilized in cancer research^[1].

IC₅₀ & Target

PI3Kα

0.025 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.95 μM Compound: 10d, WR23	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 22480851]
HCT-116	IC₅₀	1.65 μM Compound: 10d, WR23	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 22480851]
HL-60	IC₅₀	0.34 μM Compound: 10d, WR23	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 22480851]
KB	IC₅₀	2.32 μM Compound: 10d, WR23	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 22480851]
PC-3	IC₅₀	2.02 μM Compound: 10d, WR23	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 22480851]

Molecular Weight

448.33

Formula

C₁₉H₁₈BrN₃O₃S

CAS No.

1350960-66-5

SMILES

O=S(C1=CC=C(C=C1)Br)(C2=NC3=C(N=C2N4CCC(CC4)O)C=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu P, et al. Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors. Bioorg Med Chem. 2012 May 1;20(9):2837-44. [Content Brief]

PI3Kα-IN-24 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-241350960-66-5PI3KPhosphoinositide 3-kinasePI3Kα inhibitorpAkt Ser473cancerInhibitorinhibitorinhibit

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