PI3Kγ inhibitor 4 

PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC₅₀ of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation^[1].

PI3Kγ inhibitor 4 inhibits PI3Kγ and PI3Kα in U937 cells, with IC₅₀s of 120 nM and 6250 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kγ inhibitor 4 (10-20 mg/kg; a single p.o.) dose dependently inhibits the amplitude of the enhanced pause (ΔPenh) response to ovalbumin in a model of airway inflammation^[1].
PI3Kγ inhibitor 4 (a single p.o.) exhibits high oral bioavailability (72, 94 and 122%) and C_max (1.53, 12.2 and 25.2 μM) following oral administration (10, 100 and 300 mg/kg) in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

416.49

C₂₀H₂₄N₄O₄S

1821038-80-5

O=S(C1=CC=C(C)C(C2=CC(C3=CN=C(C)O3)=C(N)N=C2)=C1)(NCC(C)(O)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bellenie BR, et, al. Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ. J Med Chem. 2021 Aug 26;64(16):12304-12321.  [Content Brief]