2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Apoptosis
  4. PIK-C98

PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma.

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PIK-C98 Chemical Structure

PIK-C98 Chemical Structure

CAS No. : 691388-62-2

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PIK-C98 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1].

IC50 & Target[1]

PI3Kα

0.59 μM (IC50)

PI3Kβ

1.64 μM (IC50)

PI3Kδ

3.65 μM (IC50)

PI3Kγ

0.74 μM (IC50)

Molecular Weight

349.23

Formula

C16H10Cl2N2OS
CAS No.
SMILES

N#C/C(C(N)=S)=C\C=C\C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PIK-C98 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIK-C98691388-62-2PI3KApoptosisPhosphoinositide 3-kinaseATP-binding pocketmultiple myelomaInhibitorinhibitorinhibit

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