2. JAK/STAT Signaling
  3. Pim
  4. Pim-1/2 kinase inhibitor 2

Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines.

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Pim-1/2 kinase inhibitor 2 Chemical Structure

Pim-1/2 kinase inhibitor 2 Chemical Structure

CAS No. : 2918764-16-4

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Pim-1/2 kinase inhibitor 2 Related Antibodies

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Description

Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines[1].

IC50 & Target[1]

PIM1

1.31 μM (IC50)

PIM2

0.67 μM (IC50)

Molecular Weight

458.90

Formula

C25H19ClN4O3
CAS No.
SMILES

N#CC1=C(C2=CC3=CC(Cl)=CC=C3N=C2N4CCOCC4)C=C(C5=CC=CC(O)=C5)NC1=O
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Purity & Documentation
References
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Pim-1/2 kinase inhibitor 2 Related Classifications

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Keywords:

Pim-1/2 kinase inhibitor 22918764-16-4PimPim kinasesPIM-1PIM-2anticancer activityInhibitorinhibitorinhibit

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