2. JAK/STAT Signaling Apoptosis
  3. Pim Apoptosis
  4. Pim-1 kinase inhibitor 1

Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC50 of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer.

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Pim-1 kinase inhibitor 1 Chemical Structure

Pim-1 kinase inhibitor 1 Chemical Structure

CAS No. : 2803505-57-7

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Pim-1 kinase inhibitor 1 Related Antibodies

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Description

Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC50 of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.11 μM (Pim-1 kinase), 10.93 μM (MCF-7), 4.91 μM (CACO), 7.01 μM (HepG-2), 3.41 μM (HCT-116), 27.181 μM (WI-38)[1]
In Vitro

Pim-1 kinase inhibitor 1 (0-200 μM; 24 h) shows vitro cytotoxic activity to several cancer cells and affects cell apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pim-1 kinase inhibitor 1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MCF-7, CACO, HepG-2, HCT-116 and WI-38 cells
Concentration: 0-200 μM
Incubation Time: 24 hours
Result: Exhibited vitro cytotoxic activity to MCF-7, CACO, HepG-2, HCT-116 and WI-38 cell lines with IC50s of 10.93, 4.91, 7.01, 3.41 and 27.181 μM, respectively. Promoted apoptosis by increasing Casp-3, BAX and Bcl-2 concentration to achieve anti-cancer activity.
Molecular Weight

331.32

Formula

C19H13N3O3
CAS No.
SMILES

N#C/C(C(NC1=CC=C(C=C1)O)=O)=C\C2=CC3=CC=CC=C3N=C2O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pim-1 kinase inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pim-1 kinase inhibitor 12803505-57-7PimApoptosisPim kinasesquinolinecarboxamidesanticancerapoptosisADME propertiesMCF-7CACOHepG-2HCT-116Inhibitorinhibitorinhibit

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