2. Anti-infection PI3K/Akt/mTOR Epigenetics
  3. Bacterial AMPK
  4. Pinocembrin chalcone

Pinocembrin chalcone  (Synonyms: 2',4',6'-Trihydroxychalcone)

Cat. No.: HY-N7515 Purity: ≥98.0%
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Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes.

For research use only. We do not sell to patients.

Pinocembrin chalcone Chemical Structure

Pinocembrin chalcone Chemical Structure

CAS No. : 4197-97-1

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Based on 1 publication(s) in Google Scholar

Pinocembrin chalcone Related Antibodies

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Description

Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
25.4 μM
Compound: 8c
Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
[PMID: 28098449]
HEK293 IC50
33.3 μM
Compound: 8c
Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
[PMID: 28098449]
In Vitro

Pinocembrin chalcone (1.0 μg) is active at inhibiting the growth of S. aureus.[1].
Pinocembrin chalcone (10 μM, 24 h) markedly increases fatty acid oxidation rate and increases the phosphorylation of AMPKα with no cytotoxicity in C2C12 myotubes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pinocembrin chalcone Related Antibodies

Western Blot Analysis[2]

Cell Line: C2C12 myotubes
Concentration: 10 μM
Incubation Time: 24 h
Result: Stimulated AMPK phosphorylation at much lower concentrations (1 μM) within 2 h in C2C12 myotubes.
In Vivo

Pinocembrin chalcone (30 mg/kg, oral gavage, daily for 3 weeks) improves glucose tolerance and fat accumulation through fatty acid oxidation rate increase in skeletal muscle, which is mainly mediated by AMPK activation in HFD-induced diabetic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced diabetic mice[2]
Dosage: 30 mg/kg
Administration: oral gavage, daily for 3 weeks
Result: Reduced the circulating FFA levels and fat accumulation in the liver and muscles by increasing FAO, which improved glucose tolerance in HFD-induced diabetic mice.
Molecular Weight

256.25

Formula

C15H12O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(O)C=C(O)C=C1O)/C=C/C2=CC=CC=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: ≥98.0%

SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References
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Pinocembrin chalcone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinocembrin chalcone4197-97-12',4',6'-TrihydroxychalconeBacterialAMPKAMP-activated protein kinaseantibacterial compoundglucose toleranceFAOfat accumulationhigh-fat diet-induced diabetic micegastric ulcersdiabetesInhibitorinhibitorinhibit

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