2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis
  3. PPAR Ferroptosis
  4. Pioglitazone-d4

Pioglitazone-d4  (Synonyms: U 72107-d4)

Cat. No.: HY-13956S Purity: 99.34%
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Pioglitazone-d4 is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1].

For research use only. We do not sell to patients.

Pioglitazone-d<sub>4</sub> Chemical Structure

Pioglitazone-d4 Chemical Structure

CAS No. : 1134163-29-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Pioglitazone-d4:

Pioglitazone-d4 Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

Pioglitazone-d4 is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1].

Molecular Weight

360.46

Formula

C19H16D4N2O3S
CAS No.
Unlabeled CAS

111025-46-8
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)SC(CC2=C([2H])C([2H])=C(OCCC3=NC=C(CC)C=C3)C([2H])=C2[2H])C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 2.5 mg/mL (6.94 mM)

DMF : ≥ 2.5 mg/mL (6.94 mM)

DMSO : ≥ 2.5 mg/mL (6.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 2.5 mg/mL (6.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7742 mL 13.8712 mL 27.7423 mL
5 mM 0.5548 mL 2.7742 mL 5.5485 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / DMF / DMSO / DMSO 1 mM 2.7742 mL 13.8712 mL 27.7423 mL 69.3558 mL
5 mM 0.5548 mL 2.7742 mL 5.5485 mL 13.8712 mL
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Pioglitazone-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pioglitazone-d41134163-29-3U 72107-d4PPARFerroptosisPeroxisome proliferator-activated receptorsPPARγligand-bindingdomainInhibitorinhibitorinhibit

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