2. Metabolic Enzyme/Protease
  3. Dihydrofolate reductase (DHFR)
  4. Piritrexim

Piritrexim  (Synonyms: BW 301U; NSC 351521)

Cat. No.: HY-106434 Purity: 99.68%
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Piritrexim (BW 301U) is a potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 values of 0.038 and 0.011 μM, respectively. Piritrexim can be used for acquired immune deficiency syndrome (AIDS) research. Piritrexim also is an anticancer agent.

For research use only. We do not sell to patients.

Piritrexim Chemical Structure

Piritrexim Chemical Structure

CAS No. : 72732-56-0

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Based on 1 publication(s) in Google Scholar

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Piritrexim Related Antibodies

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Description

Piritrexim (BW 301U) is a potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 values of 0.038 and 0.011 μM, respectively. Piritrexim can be used for acquired immune deficiency syndrome (AIDS) research. Piritrexim also is an anticancer agent[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
0.013 μM
Compound: 5
Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture
Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture
[PMID: 15974594]
Molecular Weight

325.37

Formula

C17H19N5O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=C(CC2=C(C=CC(OC)=C2)OC)C=NC3=NC(N)=NC(N)=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Piritrexim Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Piritrexim72732-56-0BW 301U NSC 351521NSC351521NSC 351521NSC-351521Dihydrofolate reductase (DHFR)Pneumocystis cariniiToxoplasma gondiiAIDSanticancerInhibitorinhibitorinhibit

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