2. PI3K/Akt/mTOR
  3. PI3K
  4. PKN3-IN-1

PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine protein kinase 3) and GAK (cyclin G-associated kinase) with IC50 of 0.014 μM and Ki of 0.0044 μM respectively. PKN3-IN-1 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia .

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PKN3-IN-1 Chemical Structure

PKN3-IN-1 Chemical Structure

CAS No. : 2361545-75-5

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PKN3-IN-1 Related Antibodies

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Description

PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine protein kinase 3) and GAK (cyclin G-associated kinase) with IC50 of 0.014 μM and Ki of 0.0044 μM respectively. PKN3-IN-1 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia [1].

In Vitro

PKN3-IN-1 inhibits (1 μM, 48 h) PKN3 with an IC50 of 0.014 μM in HEK 293 cells[1].
PKN3-IN-1 (1 μM, 24 h) inhibits GAK with a Ki of 0.0044 μM in HEK 293 cells[2].
PKN3-IN-1 (1.3 μM) has in cell target engagement potencies under 5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PKN3-IN-1 Related Antibodies
Molecular Weight

436.24

Formula

C18H17IN2O3
CAS No.
SMILES

IC1=CC2=NC=CC(NC3=CC(OC)=C(C(OC)=C3)OC)=C2C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PKN3-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKN3-IN-12361545-75-5PI3KPhosphoinositide 3-kinaseprotein kinasecancerHEK293 cellsInhibitorinhibitorinhibit

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