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  4. (+)-Coclaurine hydrochloride

(+)-Coclaurine hydrochloride  (Synonyms: (+)-(R)-Coclaurine hydrochloride; (R)-Coclaurine hydrochloride; d-Coclaurine hydrochloride)

Cat. No.: HY-N2550A Purity: 99.09%
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(+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride, benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine hydrochloride has anti-aging activity.

For research use only. We do not sell to patients.

(+)-Coclaurine hydrochloride Chemical Structure

(+)-Coclaurine hydrochloride Chemical Structure

CAS No. : 19894-19-0

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Based on 1 publication(s) in Google Scholar

Other Forms of (+)-Coclaurine hydrochloride:

(+)-Coclaurine hydrochloride Related Antibodies

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Description

(+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride, benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine hydrochloride has anti-aging activity[1][2].

In Vivo

An intracerebroventricular injection of (+)-Coclaurine (d-Coclaurine; 50 μg) hydrochloride produces a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. (+)-Coclaurine hydrochloride blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

321.80

Formula

C17H20ClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C(CCN1)C([C@H]1CC2=CC=C(C=C2)O)=C3)=C3O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (155.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 5 mg/mL (15.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1075 mL 15.5376 mL 31.0752 mL
5 mM 0.6215 mL 3.1075 mL 6.2150 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.1075 mL 15.5376 mL 31.0752 mL 77.6880 mL
5 mM 0.6215 mL 3.1075 mL 6.2150 mL 15.5376 mL
10 mM 0.3108 mL 1.5538 mL 3.1075 mL 7.7688 mL
15 mM 0.2072 mL 1.0358 mL 2.0717 mL 5.1792 mL
DMSO 20 mM 0.1554 mL 0.7769 mL 1.5538 mL 3.8844 mL
25 mM 0.1243 mL 0.6215 mL 1.2430 mL 3.1075 mL
30 mM 0.1036 mL 0.5179 mL 1.0358 mL 2.5896 mL
40 mM 0.0777 mL 0.3884 mL 0.7769 mL 1.9422 mL
50 mM 0.0622 mL 0.3108 mL 0.6215 mL 1.5538 mL
60 mM 0.0518 mL 0.2590 mL 0.5179 mL 1.2948 mL
80 mM 0.0388 mL 0.1942 mL 0.3884 mL 0.9711 mL
100 mM 0.0311 mL 0.1554 mL 0.3108 mL 0.7769 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(+)-Coclaurine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Coclaurine19894-19-0(+)-(R)-Coclaurine(R)-Coclaurined-CoclaurineOthersBenzyltetrahydroisoquinoline alkaloidpostsynapticInhibitorinhibitorinhibit

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