2. Natural Products
  3. Plants Alkaloids Phenols
  4. Lauraceae Isoquinoline Alkaloids Polyphenols
  5. Lindera aggregata (Sims) Kosterm.
  6. (+)-Coclaurine

(+)-Coclaurine  (Synonyms: (+)-(R)-Coclaurine; (R)-Coclaurine; d-Coclaurine)

Cat. No.: HY-N2550
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(+)-Coclaurine ((+)-(R)-Coclaurine), benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine has anti-aging activity.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form ((+)-Coclaurine hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

(+)-Coclaurine Chemical Structure

(+)-Coclaurine Chemical Structure

CAS No. : 2196-60-3

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Other Forms of (+)-Coclaurine:

(+)-Coclaurine Related Antibodies

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Description

(+)-Coclaurine ((+)-(R)-Coclaurine), benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine has anti-aging activity[1][2].

In Vivo

An intracerebroventricular injection of (+)-Coclaurine (d-Coclaurine; 50 μg) produces a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. (+)-Coclaurine blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

285.34

Formula

C17H19NO3
CAS No.
SMILES

OC(C=C1)=CC=C1C[C@@H]2C3=CC(O)=C(OC)C=C3CCN2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (87.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5046 mL 17.5230 mL 35.0459 mL
5 mM 0.7009 mL 3.5046 mL 7.0092 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5046 mL 17.5230 mL 35.0459 mL 87.6148 mL
5 mM 0.7009 mL 3.5046 mL 7.0092 mL 17.5230 mL
10 mM 0.3505 mL 1.7523 mL 3.5046 mL 8.7615 mL
15 mM 0.2336 mL 1.1682 mL 2.3364 mL 5.8410 mL
20 mM 0.1752 mL 0.8761 mL 1.7523 mL 4.3807 mL
25 mM 0.1402 mL 0.7009 mL 1.4018 mL 3.5046 mL
30 mM 0.1168 mL 0.5841 mL 1.1682 mL 2.9205 mL
40 mM 0.0876 mL 0.4381 mL 0.8761 mL 2.1904 mL
50 mM 0.0701 mL 0.3505 mL 0.7009 mL 1.7523 mL
60 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4602 mL
80 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0952 mL
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(+)-Coclaurine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Coclaurine2196-60-3(+)-(R)-Coclaurine (R)-Coclaurine d-CoclaurineOthersBenzyltetrahydroisoquinolinealkaloidpostsynapticInhibitorinhibitorinhibit

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