2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. PM050489

PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research.

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PM050489 Chemical Structure

PM050489 Chemical Structure

CAS No. : 960210-97-3

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PM050489 Related Antibodies

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Description

PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research[1][2].

IC50 & Target

Mitosis[1]
In Vitro

PM050489 inhibits the activity of HT-29, A-549 and MDA-MB-231 cells with GI50 values of 0.46 nM, 0.38 nM and 0.45 nM, respectively[1].
PM050489 (0.01 nM and 0.1 nM; 24 h) destroys the morphology of microtubule networks and mitotic spindles in A549 cells[2].
PM050489 (0.01, 0.1, 1 and 10 nM) inhibits tubulin polymerization with dose-dependent manner in A549 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PM050489 Related Antibodies

Cell Cycle Analysis[2]

Cell Line: A549 cells.
Concentration: 0.25 nM.
Incubation Time: 20 h.
Result: Induced A549 cell cycle arrest in G2/M phase.
Molecular Weight

606.15

Formula

C31H44ClN3O7
CAS No.
SMILES

C/C(Cl)=C\C[C@H](OC(N)=O)C/C=C\NC([C@H](C(C)(C)C)NC(/C=C\C=C/C(C)=C/[C@@H]([C@@]1([H])OC(C(OC)=CC1)=O)C)=O)=O
Structure Classification
Initial Source

Lithoplocamia lithistoides
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PM050489 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PM050489960210-97-3PM 050489PM-050489Microtubule/TubulinA549 cellsHT-29 cellsMDA-MB-231 cellsMicrotubuleTubulinMitotic spindlesInhibitorinhibitorinhibit

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