PMEDAP

Name: PMEDAP
Brand: MedChemExpress
SKU: HY-106382
Rating: 4.5 (1 reviews)

Cat. No.: HY-106382 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality.

For research use only. We do not sell to patients.

PMEDAP Chemical Structure

CAS No. : 113852-41-8

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5 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 494	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 767	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1190	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-HSB-2	CC₅₀	> 56 μM Compound: PME-DAP	Cytotoxicity against human HSB2 cell after 4 hrs by MTS assay Cytotoxicity against human HSB2 cell after 4 hrs by MTS assay	[PMID: 18852272]
Daudi	CC₅₀	> 50 μM Compound: PME-DAP	Cytotoxicity against human Daudi cell after 4 hrs by MTS assay Cytotoxicity against human Daudi cell after 4 hrs by MTS assay	[PMID: 18852272]
HEL 299	EC₅₀	> 173 μM Compound: 3b, PMEDAP	Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining	[PMID: 17893157]
HEL 299	EC₅₀	> 173 μM Compound: 3b, PMEDAP	Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining	[PMID: 17893157]
HEL 299	CC₅₀	100 μM Compound: 3b, PMEDAP	Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis	[PMID: 17893157]
HFF	EC₅₀	> 10 μM Compound: PME-DAP	Antiviral activity against herpes simplex virus 1 E-377 infected in HFF cells by plaque reduction assay Antiviral activity against herpes simplex virus 1 E-377 infected in HFF cells by plaque reduction assay	[PMID: 18852272]
HFF	EC₅₀	> 10 μM Compound: PME-DAP	Antiviral activity against herpes simplex virus 2 MS infected in HFF cells by plaque reduction assay Antiviral activity against herpes simplex virus 2 MS infected in HFF cells by plaque reduction assay	[PMID: 18852272]
HFF	CC₅₀	> 100 μM Compound: PME-DAP	Cytotoxicity against human HFF cells after 7 days by neutral red dye method Cytotoxicity against human HFF cells after 7 days by neutral red dye method	[PMID: 18852272]
HFF	EC₅₀	0.2 μM Compound: PME-DAP	Antiviral activity against Murine cytomegalovirus Smith infected in HFF cells by plaque reduction assay Antiviral activity against Murine cytomegalovirus Smith infected in HFF cells by plaque reduction assay	[PMID: 18852272]
HFF	EC₅₀	13 μM Compound: PME-DAP	Antiviral activity against Human cytomegalovirus AD169 infected in HFF cells by plaque reduction assay Antiviral activity against Human cytomegalovirus AD169 infected in HFF cells by plaque reduction assay	[PMID: 18852272]
HFF	EC₅₀	2.9 μM Compound: PME-DAP	Antiviral activity against Varicella zoster virus Ellen infected in HFF cells by plaque reduction assay Antiviral activity against Varicella zoster virus Ellen infected in HFF cells by plaque reduction assay	[PMID: 18852272]
MOLT-3	CC₅₀	39 μM Compound: PME-DAP	Cytotoxicity against human MOLT3 cell after 4 hrs by MTS assay Cytotoxicity against human MOLT3 cell after 4 hrs by MTS assay	[PMID: 18852272]

In Vivo

PMEDAP (0.25-5 mg/kg; IP; daily; starting on the day of MSV-infected and continuing for an additional four days) causes a dose-dependent suppression of tumor formation and mortality in newborn mice inoculated with MSV^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Three-week-old male NMRI mice^[1]
Dosage:	0.25 mg/kg, 1 mg/kg, 5 mg/kg
Administration:	IP; daily; starting on the day of infection and continuing for an additional four days
Result:	Effected a significant delay in tumor appearance and an enhancement of the survival rate of tumor-bearing mice.

Molecular Weight

288.20

Formula

C₈H₁₃N₆O₄P

CAS No.

113852-41-8

Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(COCCN1C=NC2=C1N=C(N)N=C2N)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

0.1 M NaOH : 14.29 mg/mL (49.58 mM; ultrasonic and adjust pH to 12 with NaOH)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4698 mL	17.3491 mL	34.6981 mL
5 mM	0.6940 mL	3.4698 mL	6.9396 mL
10 mM	0.3470 mL	1.7349 mL	3.4698 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) HNMR (256 KB)

Handling Instructions (2659 KB)

References

[1]. Neyts J, et al. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo [published correction appears in Eur J Clin Microbiol Infect Dis 1993 Jul;12(7):following 477]. Eur J Clin Microbio [Content Brief]

[2]. Naesens L, et al. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis. 1989;8(12):10 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

0.1 M NaOH	1 mM	3.4698 mL	17.3491 mL	34.6981 mL	86.7453 mL
	5 mM	0.6940 mL	3.4698 mL	6.9396 mL	17.3491 mL
	10 mM	0.3470 mL	1.7349 mL	3.4698 mL	8.6745 mL
	15 mM	0.2313 mL	1.1566 mL	2.3132 mL	5.7830 mL
	20 mM	0.1735 mL	0.8675 mL	1.7349 mL	4.3373 mL
	25 mM	0.1388 mL	0.6940 mL	1.3879 mL	3.4698 mL
	30 mM	0.1157 mL	0.5783 mL	1.1566 mL	2.8915 mL
	40 mM	0.0867 mL	0.4337 mL	0.8675 mL	2.1686 mL

PMEDAP Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PMEDAP113852-41-8HIVCMVHuman immunodeficiency virusCytomegalovirusvirusreplicationsarcomamortalitymiceInhibitorinhibitorinhibit

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PMEDAP

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PMEDAP Related Antibodies

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•Related Screening Libraries:

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•Related Proteins:

View All HIV Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

PMEDAP Related Classifications

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SAFETY DATA SHEET (SDS)

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