PNU-22394 hydrochloride

Cat. No.: HY-103145 Purity: 98.79%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

PNU-22394 hydrochloride is an agonist for 5-HT, with K_i of 6.1 and 10 nM, for 5-HT_2C and 5-HT_2A, respectively.

For research use only. We do not sell to patients.

PNU-22394 hydrochloride Chemical Structure

CAS No. : 15923-42-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

PNU-22394 hydrochloride is an agonist for 5-HT, with K_i of 6.1 and 10 nM, for 5-HT_2C and 5-HT_2A, respectively^[1].

In Vivo

PNU-22394 hydrochloride exhibits agonistic efficacy for 5-HT_2C and 5-HT_2A, with EC₅₀ of 7.7 and 23 nM (measured via the Fluo-4/Ca²⁺ Assay), or 0.12 and 0.21 μM (measured via IP-One Assay), while the R_max is 97%-102%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

236.74

Formula

C₁₃H₁₇ClN₂

CAS No.

15923-42-9

Appearance

Solid

Color

White to off-white

SMILES

CN1C(CCNCC2)=C2C3=C1C=CC=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1056.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2240 mL	21.1202 mL	42.2404 mL
5 mM	0.8448 mL	4.2240 mL	8.4481 mL
10 mM	0.4224 mL	2.1120 mL	4.2240 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.79%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (253 KB) HNMR (242 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Ennis MD, et al., 2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2369-72. [Content Brief]

[2]. Jensen AA, et al., Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. J Med Chem. 2013 Feb 14;56(3):1211-27. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2240 mL	21.1202 mL	42.2404 mL	105.6011 mL
	5 mM	0.8448 mL	4.2240 mL	8.4481 mL	21.1202 mL
	10 mM	0.4224 mL	2.1120 mL	4.2240 mL	10.5601 mL
	15 mM	0.2816 mL	1.4080 mL	2.8160 mL	7.0401 mL
	20 mM	0.2112 mL	1.0560 mL	2.1120 mL	5.2801 mL
	25 mM	0.1690 mL	0.8448 mL	1.6896 mL	4.2240 mL
	30 mM	0.1408 mL	0.7040 mL	1.4080 mL	3.5200 mL
	40 mM	0.1056 mL	0.5280 mL	1.0560 mL	2.6400 mL
	50 mM	0.0845 mL	0.4224 mL	0.8448 mL	2.1120 mL
	60 mM	0.0704 mL	0.3520 mL	0.7040 mL	1.7600 mL
	80 mM	0.0528 mL	0.2640 mL	0.5280 mL	1.3200 mL
	100 mM	0.0422 mL	0.2112 mL	0.4224 mL	1.0560 mL