Poly(2-hydroxyethyl methacrylate) (Mv 20000)

Cat. No.: HY-112531: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Poly(2-hydroxyethyl methacrylate) (MW 20000) is one of the most important hydrogels in the biomaterials world. Poly(2-hydroxyethyl methacrylate) is the basic component of contact lenses, and is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agent and etc.

For research use only. We do not sell to patients.

Poly(2-hydroxyethyl methacrylate) (Mv 20000) Chemical Structure

CAS No. : 25249-16-5

Size	Price	Stock	Quantity
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
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Description	Poly(2-hydroxyethyl methacrylate) (MW 20000) is one of the most important hydrogels in the biomaterials world. Poly(2-hydroxyethyl methacrylate) is the basic component of contact lenses, and is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agent and etc^[1].
In Vitro	Poly(2-hydroxyethyl methacrylate) (PolyHEMA) retains moisture content similar to the live tissue and is resistant to degradation and absorption by the host cells. It can be easily manufactured in a variety of shapes and can be readily sterilized^[1]. Proliferation rate of the cells that had been cultured on Poly(2-hydroxyethyl methacrylate) is reduced; Poly(2-hydroxyethyl methacrylate) does not induce cell death in the hRPE cultures. Human retinal pigment epithelium (RPE) cells cultured on Poly(2-hydroxyethyl methacrylate) formed many giant spheroid colonies. The giant colonies are re-cultured and the presence of retinal progenitor markers and markers of hRPE cells are detected in cell cultures on Poly(2-hydroxyethyl methacrylate)^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Poly(2-hydroxyethyl methacrylate) (Mv 20000) Related Antibodies
Molecular Weight	20000(Average)
CAS No.	25249-16-5
Appearance	Solid
Color	White to off-white
SMILES	OCCOC(C(C)(C)CC)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility	In Vitro: Ethanol : 50 mg/mL (Need ultrasonic) Molarity Calculator Dilution Calculator Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass = Concentration × Volume × Molecular Weight * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ Concentration _(start) C1 × Volume _(start) V1 = Concentration _(final) C2 × Volume _(final) V2 In Vivo: Select the appropriate dissolution method based on your experimental animal and administration route. For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents: To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day. The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution. Protocol 1 Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline Solubility: ≥ 2.5 mg/mL; Clear solution This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL. Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution. Protocol 2 Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline) Solubility: 2.5 mg/mL; Suspended solution; Need ultrasonic This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection. Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear. Protocol 3 Add each solvent one by one: 10% EtOH 90% Corn Oil Solubility: ≥ 2.5 mg/mL; Clear solution This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully. Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly. In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL
Purity & Documentation	Select Batch: Data Sheet (271 KB) SDS (251 KB) COA (247 KB) Handling Instructions (2659 KB)
References	[1]. Fatemeh Nazemroaya, et al. Induced Retro-Differentiation of Human Retinal Pigment Epithelial Cells on PolyHEMA. J Cell Biochem. 2017 Oct;118(10):3080-3089. [Content Brief]