2. Anti-infection
  3. Antibiotic Bacterial
  4. Polymyxin B2

Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Polymyxin B2 Chemical Structure

Polymyxin B2 Chemical Structure

CAS No. : 34503-87-2

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Based on 1 publication(s) in Google Scholar

Polymyxin B2 Related Antibodies

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Description

Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains[1].

Cellular Effect
Cell Line Type Value Description References
Vero CC50
159 μg/mL
Compound: Polymyxin B2
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
[PMID: 29412662]
Molecular Weight

1189.45

Formula

C55H96N16O13
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (105.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8407 mL 4.2036 mL 8.4072 mL
5 mM 0.1681 mL 0.8407 mL 1.6814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8407 mL 4.2036 mL 8.4072 mL 21.0181 mL
5 mM 0.1681 mL 0.8407 mL 1.6814 mL 4.2036 mL
10 mM 0.0841 mL 0.4204 mL 0.8407 mL 2.1018 mL
15 mM 0.0560 mL 0.2802 mL 0.5605 mL 1.4012 mL
20 mM 0.0420 mL 0.2102 mL 0.4204 mL 1.0509 mL
25 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.8407 mL
30 mM 0.0280 mL 0.1401 mL 0.2802 mL 0.7006 mL
40 mM 0.0210 mL 0.1051 mL 0.2102 mL 0.5255 mL
50 mM 0.0168 mL 0.0841 mL 0.1681 mL 0.4204 mL
60 mM 0.0140 mL 0.0701 mL 0.1401 mL 0.3503 mL
80 mM 0.0105 mL 0.0525 mL 0.1051 mL 0.2627 mL
100 mM 0.0084 mL 0.0420 mL 0.0841 mL 0.2102 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Polymyxin B2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polymyxin B234503-87-2Polymyxin B 2Polymyxin B-2AntibioticBacterialGram-negative bacteriaantibioticslipopolysaccharidesdrug-resistant strainsInhibitorinhibitorinhibit

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