2. PROTAC
  3. Ligands for E3 Ligase
  4. Pomalidomide-6-O-CH3

Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC.

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Pomalidomide-6-O-CH3 Chemical Structure

Pomalidomide-6-O-CH3 Chemical Structure

CAS No. : 1547163-08-5

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Pomalidomide-6-O-CH3 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-6-O-CH3 Related Antibodies
Molecular Weight

303.27

Formula

C14H13N3O5
CAS No.
SMILES

O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(N)=CC(OC)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pomalidomide-6-O-CH3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-6-O-CH31547163-08-5Ligands for E3 LigaseE3 ligase-recruiting MoietyCRBNPROTACPomalidomideInhibitorinhibitorinhibit

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