2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-amino-PEG3-NH2 hydrochloride

Pomalidomide-amino-PEG3-NH2 hydrochloride 

Cat. No.: HY-133817 Purity: 99.52%
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Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-amino-PEG3-NH2 hydrochloride Chemical Structure

Pomalidomide-amino-PEG3-NH2 hydrochloride Chemical Structure

CAS No. : 2380273-75-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Pomalidomide-amino-PEG3-NH2 hydrochloride:

Pomalidomide-amino-PEG3-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • Purity & Documentation

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Description

Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-amino-PEG3-NH2 hydrochloride Related Antibodies
Molecular Weight

498.91

Formula

C21H27ClN4O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (200.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0044 mL 10.0218 mL 20.0437 mL
5 mM 0.4009 mL 2.0044 mL 4.0087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0044 mL 10.0218 mL 20.0437 mL 50.1092 mL
5 mM 0.4009 mL 2.0044 mL 4.0087 mL 10.0218 mL
10 mM 0.2004 mL 1.0022 mL 2.0044 mL 5.0109 mL
15 mM 0.1336 mL 0.6681 mL 1.3362 mL 3.3406 mL
20 mM 0.1002 mL 0.5011 mL 1.0022 mL 2.5055 mL
25 mM 0.0802 mL 0.4009 mL 0.8017 mL 2.0044 mL
30 mM 0.0668 mL 0.3341 mL 0.6681 mL 1.6703 mL
40 mM 0.0501 mL 0.2505 mL 0.5011 mL 1.2527 mL
50 mM 0.0401 mL 0.2004 mL 0.4009 mL 1.0022 mL
60 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8352 mL
80 mM 0.0251 mL 0.1253 mL 0.2505 mL 0.6264 mL
100 mM 0.0200 mL 0.1002 mL 0.2004 mL 0.5011 mL
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Pomalidomide-amino-PEG3-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-amino-PEG3-NH22380273-75-4E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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