2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-amino-PEG5-NH2 hydrochloride

Pomalidomide-amino-PEG5-NH2 hydrochloride 

Cat. No.: HY-133816 Purity: 99.58%
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Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-amino-PEG5-NH2 hydrochloride Chemical Structure

Pomalidomide-amino-PEG5-NH2 hydrochloride Chemical Structure

CAS No. : 2421217-05-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Pomalidomide-amino-PEG5-NH2 hydrochloride:

Pomalidomide-amino-PEG5-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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  • Purity & Documentation

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Description

Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-amino-PEG5-NH2 hydrochloride Related Antibodies
Molecular Weight

587.02

Formula

C25H35ClN4O10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCOCCOCCN.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 105 mg/mL (178.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7035 mL 8.5176 mL 17.0352 mL
5 mM 0.3407 mL 1.7035 mL 3.4070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7035 mL 8.5176 mL 17.0352 mL 42.5880 mL
5 mM 0.3407 mL 1.7035 mL 3.4070 mL 8.5176 mL
10 mM 0.1704 mL 0.8518 mL 1.7035 mL 4.2588 mL
15 mM 0.1136 mL 0.5678 mL 1.1357 mL 2.8392 mL
20 mM 0.0852 mL 0.4259 mL 0.8518 mL 2.1294 mL
25 mM 0.0681 mL 0.3407 mL 0.6814 mL 1.7035 mL
30 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4196 mL
40 mM 0.0426 mL 0.2129 mL 0.4259 mL 1.0647 mL
50 mM 0.0341 mL 0.1704 mL 0.3407 mL 0.8518 mL
60 mM 0.0284 mL 0.1420 mL 0.2839 mL 0.7098 mL
80 mM 0.0213 mL 0.1065 mL 0.2129 mL 0.5323 mL
100 mM 0.0170 mL 0.0852 mL 0.1704 mL 0.4259 mL
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Pomalidomide-amino-PEG5-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-amino-PEG5-NH22421217-05-0E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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