2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-C3-NHS ester

Pomalidomide-C3-NHS ester is a synthesized E3 ligase ligand-linker conjugate, incorporating the Pomalidomide based cereblon ligand and NHS ester linker.

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Pomalidomide-C3-NHS ester Chemical Structure

Pomalidomide-C3-NHS ester Chemical Structure

CAS No. : 2828476-87-3

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Based on 1 publication(s) in Google Scholar

Pomalidomide-C3-NHS ester Related Antibodies

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Description

Pomalidomide-C3-NHS ester is a synthesized E3 ligase ligand-linker conjugate, incorporating the Pomalidomide based cereblon ligand and NHS ester linker.

IC50 & Target

Cereblon

 

Molecular Weight

456.41

Formula

C21H20N4O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C2C=CC=C1NCCCC(ON3C(CCC3=O)=O)=O)N(C4C(NC(CC4)=O)=O)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1910 mL 10.9551 mL 21.9101 mL
5 mM 0.4382 mL 2.1910 mL 4.3820 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1910 mL 10.9551 mL 21.9101 mL 54.7753 mL
5 mM 0.4382 mL 2.1910 mL 4.3820 mL 10.9551 mL
10 mM 0.2191 mL 1.0955 mL 2.1910 mL 5.4775 mL
15 mM 0.1461 mL 0.7303 mL 1.4607 mL 3.6517 mL
20 mM 0.1096 mL 0.5478 mL 1.0955 mL 2.7388 mL
25 mM 0.0876 mL 0.4382 mL 0.8764 mL 2.1910 mL
30 mM 0.0730 mL 0.3652 mL 0.7303 mL 1.8258 mL
40 mM 0.0548 mL 0.2739 mL 0.5478 mL 1.3694 mL
50 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0955 mL
60 mM 0.0365 mL 0.1826 mL 0.3652 mL 0.9129 mL
80 mM 0.0274 mL 0.1369 mL 0.2739 mL 0.6847 mL
100 mM 0.0219 mL 0.1096 mL 0.2191 mL 0.5478 mL
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Pomalidomide-C3-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C3-NHS ester2828476-87-3E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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