2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-PEG1-NH2 hydrochloride

Pomalidomide-PEG1-NH2 hydrochloride 

Cat. No.: HY-136772 Purity: 97.05%
COA Handling Instructions

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Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand.

For research use only. We do not sell to patients.

Pomalidomide-PEG1-NH2 hydrochloride Chemical Structure

Pomalidomide-PEG1-NH2 hydrochloride Chemical Structure

CAS No. : 2380273-67-4

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5 mg USD 210 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 1150 In-stock
100 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

Pomalidomide-PEG1-NH2 hydrochloride Related Antibodies

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Description

Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand[1].

Molecular Weight

410.81

Formula

C17H19ClN4O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Cl.NCCOCC(NC1=CC=CC(C2=O)=C1C(N2C(C3=O)CCC(N3)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (152.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4342 mL 12.1711 mL 24.3422 mL
5 mM 0.4868 mL 2.4342 mL 4.8684 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4342 mL 12.1711 mL 24.3422 mL 60.8554 mL
5 mM 0.4868 mL 2.4342 mL 4.8684 mL 12.1711 mL
10 mM 0.2434 mL 1.2171 mL 2.4342 mL 6.0855 mL
15 mM 0.1623 mL 0.8114 mL 1.6228 mL 4.0570 mL
20 mM 0.1217 mL 0.6086 mL 1.2171 mL 3.0428 mL
25 mM 0.0974 mL 0.4868 mL 0.9737 mL 2.4342 mL
30 mM 0.0811 mL 0.4057 mL 0.8114 mL 2.0285 mL
40 mM 0.0609 mL 0.3043 mL 0.6086 mL 1.5214 mL
50 mM 0.0487 mL 0.2434 mL 0.4868 mL 1.2171 mL
60 mM 0.0406 mL 0.2029 mL 0.4057 mL 1.0143 mL
80 mM 0.0304 mL 0.1521 mL 0.3043 mL 0.7607 mL
100 mM 0.0243 mL 0.1217 mL 0.2434 mL 0.6086 mL
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Pomalidomide-PEG1-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-PEG1-NH22380273-67-4E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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