2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Prednisolone disodium phosphate

Prednisolone disodium phosphate  (Synonyms: Prednisolone 21-phosphate disodium)

Cat. No.: HY-B0645 Purity: 99.79%
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Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

For research use only. We do not sell to patients.

Prednisolone disodium phosphate Chemical Structure

Prednisolone disodium phosphate Chemical Structure

CAS No. : 125-02-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 79 In-stock
Solution
10 mM * 1 mL in Water USD 79 In-stock
Solid
100 mg USD 72 In-stock
500 mg USD 96 In-stock
1 g   Get quote  
5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Prednisolone disodium phosphate:

Prednisolone disodium phosphate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Prednisolone disodium phosphate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Target: Glucocorticoid Receptor Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].

Molecular Weight

484.39

Formula

C21H27Na2O8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1([C@@]2(O)C(COP(O[Na])(O[Na])=O)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@@H](O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (103.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0645 mL 10.3223 mL 20.6445 mL
5 mM 0.4129 mL 2.0645 mL 4.1289 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (206.45 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0645 mL 10.3223 mL 20.6445 mL 51.6113 mL
5 mM 0.4129 mL 2.0645 mL 4.1289 mL 10.3223 mL
10 mM 0.2064 mL 1.0322 mL 2.0645 mL 5.1611 mL
15 mM 0.1376 mL 0.6882 mL 1.3763 mL 3.4408 mL
20 mM 0.1032 mL 0.5161 mL 1.0322 mL 2.5806 mL
25 mM 0.0826 mL 0.4129 mL 0.8258 mL 2.0645 mL
30 mM 0.0688 mL 0.3441 mL 0.6882 mL 1.7204 mL
40 mM 0.0516 mL 0.2581 mL 0.5161 mL 1.2903 mL
50 mM 0.0413 mL 0.2064 mL 0.4129 mL 1.0322 mL
60 mM 0.0344 mL 0.1720 mL 0.3441 mL 0.8602 mL
80 mM 0.0258 mL 0.1290 mL 0.2581 mL 0.6451 mL
100 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.5161 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Prednisolone disodium phosphate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prednisolone disodium125-02-0Prednisolone 21-phosphate disodiumGlucocorticoid ReceptorInhibitorinhibitorinhibit

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