Pretomanid-d₄

Cat. No.: HY-10844S Purity: 99.39%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pretomanid-d4 is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL[1][2].

For research use only. We do not sell to patients.

Pretomanid-d<sub>4</sub> Chemical Structure

Pretomanid-d₄ Chemical Structure

CAS No. : 1346617-34-2

Size	Price	Stock	Quantity
500 μg	USD 1120	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of Pretomanid-d₄:

Pretomanid In-stock

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

363.28

Formula

C₁₄H₈D₄F₃N₃O₅

CAS No.

1346617-34-2

Unlabeled CAS

187235-37-6

Appearance

Solid

Color

White to light yellow

SMILES

O=[N+](C1=CN2C(OC[C@H](C2([2H])[2H])OC([2H])([2H])C3=CC=C(C=C3)OC(F)(F)F)=N1)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (344.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7527 mL	13.7635 mL	27.5270 mL
5 mM	0.5505 mL	2.7527 mL	5.5054 mL
10 mM	0.2753 mL	1.3763 mL	2.7527 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.39%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Stover CK, et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature. 2000 Jun 22;405(6789):962-6. [Content Brief]

[3]. Lenaerts AJ, et al. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob Agents Chemother. 2005 Jun;49(6):2294-301. [Content Brief]

[4]. Manjunatha UH, et al. Mycobacterium leprae is naturally resistant to PA-824. Antimicrob Agents Chemother. 2006 Oct;50(10):3350-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7527 mL	13.7635 mL	27.5270 mL	68.8174 mL
	5 mM	0.5505 mL	2.7527 mL	5.5054 mL	13.7635 mL
	10 mM	0.2753 mL	1.3763 mL	2.7527 mL	6.8817 mL
	15 mM	0.1835 mL	0.9176 mL	1.8351 mL	4.5878 mL
	20 mM	0.1376 mL	0.6882 mL	1.3763 mL	3.4409 mL
	25 mM	0.1101 mL	0.5505 mL	1.1011 mL	2.7527 mL
	30 mM	0.0918 mL	0.4588 mL	0.9176 mL	2.2939 mL
	40 mM	0.0688 mL	0.3441 mL	0.6882 mL	1.7204 mL
	50 mM	0.0551 mL	0.2753 mL	0.5505 mL	1.3763 mL
	60 mM	0.0459 mL	0.2294 mL	0.4588 mL	1.1470 mL
	80 mM	0.0344 mL	0.1720 mL	0.3441 mL	0.8602 mL
	100 mM	0.0275 mL	0.1376 mL	0.2753 mL	0.6882 mL

Pretomanid-d₄ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pretomanid-d₄1346617-34-2Isotope-Labeled CompoundsBacterialAntibioticInhibitorinhibitorinhibit

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Pretomanid-d4

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