2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor Urotensin Receptor
  4. PRL 3195

PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PRL 3195 Chemical Structure

PRL 3195 Chemical Structure

CAS No. : 341519-04-8

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PRL 3195 Related Antibodies

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Description

PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively)[1].

IC50 & Target[1]

hsst5

6 nM (Ki)

hsst2

17 nM (Ki)

hsst3

66 nM (Ki)

hsst1

1000 nM (Ki)

hsst4

1000 nM (Ki)

rat urotensin II receptor

429 nM (Ki)

human urotensin II receptor

1846 nM (Ki)

In Vitro

PRL 3195 inhibits human urotensin II-induced phasic oscillations of rat aorta with an ED50 of 24 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRL 3195 Related Antibodies
Molecular Weight

1177.83

Formula

C58H69ClN12O9S2
CAS No.
Sequence

{Phe<4Cl>}-{d-Cys}-{β-Ala<3-Py>}-{d-Trp}-{Lys<N2-Me>}-Thr-Cys-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
Sequence Shortening

{F<4Cl>}-{d-C}-{β-A<3-Py>}-{d-W}-{K<N2-Me>}-TC-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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PRL 3195 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRL 3195341519-04-8PRL3195PRL-3195Somatostatin ReceptorUrotensin ReceptorSSTRsSSTRUT receptorInhibitorinhibitorinhibit

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PRL 3195
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HY-P4469
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