2. Epigenetics
  3. Histone Methyltransferase
  4. PRMT5-IN-48

PRMT5-IN-48 (compound D3) is an orally effective PRMT5 inhibitor (IC50=20.7 nM) with anticancer activity. PRMT5-IN-48 can inhibit the growth of various cancer cells, induce apoptosis (apoptosis), and arrest the cell cycle at the G0/G1 phase. PRMT5-IN-48 can be used for non-Hodgkin lymphoma (NHL) research.

For research use only. We do not sell to patients.

PRMT5-IN-48 Chemical Structure

PRMT5-IN-48 Chemical Structure

CAS No. : 2640287-77-8

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PRMT5-IN-48 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

PRMT5-IN-48 (compound D3) is an orally effective PRMT5 inhibitor (IC50=20.7 nM) with anticancer activity. PRMT5-IN-48 can inhibit the growth of various cancer cells, induce apoptosis (apoptosis), and arrest the cell cycle at the G0/G1 phase. PRMT5-IN-48 can be used for non-Hodgkin lymphoma (NHL) research[1].

IC50 & Target

PRMT5[1]
Parmacokinetics
Species Dose Route Indicator value
Rat 10.000mg/kg p.o. T1/2 0.4hr
Rat 2.000mg/kg i.v. T1/2 2.2hr
Rat 10.000mg/kg p.o. Cmax 1366.5ng/mL
Rat 2.000mg/kg i.v. Tmax 0.1hr
Rat 10.000mg/kg p.o. AUC0-t 771ng·h/mL
Rat 2.000mg/kg i.v. Cmax 894ng/mL
Rat 10.000mg/kg p.o. MRT 0.5hr
Rat 2.000mg/kg i.v. AUC0-t 1028.2ng·h/mL
Rat 10.000mg/kg p.o. CL 2.5L/h/kg
Rat 2.000mg/kg i.v. MRT 1.7hr
Rat 10.000mg/kg p.o. Vd 1.4L/kg
Rat 2.000mg/kg i.v. F 26.7%
Molecular Weight

515.65

Formula

C30H37N5O3
CAS No.
SMILES

O=C1C2=CC(NC3CC4(C3)CN(C4)C(C)=O)=NC=C2C5(CN1C[C@@H](CN6CCC(C=CC=C7)=C7C6)O)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PRMT5-IN-48 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-482640287-77-8Histone MethyltransferaseInhibitorinhibitorinhibit

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HY-170792
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