2. Others Epigenetics Apoptosis
  3. Fluorescent Dye Histone Methyltransferase Apoptosis
  4. PRMT5-targeted fluorescent ligand-1

PRMT5-targeted fluorescent ligand-1 (Compound 7) is a PRMT5-targeted fluorescent ligand, that inhibits PRMT5 with an IC50 of 29.39 nM. PRMT5-targeted fluorescent ligand-1 exhibits cell imaging activity, that exhibits good fluorescence signal in MCF-7 with an IC50 of 29 nM. PRMT5-targeted fluorescent ligand-1 induces apoptosis. PRMT5-targeted fluorescent ligand-1 exhibits a maximal excitation wavelength of 438 nm and a maximal emission wavelength of 550 nm.

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PRMT5-targeted fluorescent ligand-1 Chemical Structure

PRMT5-targeted fluorescent ligand-1 Chemical Structure

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PRMT5-targeted fluorescent ligand-1 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

PRMT5-targeted fluorescent ligand-1 (Compound 7) is a PRMT5-targeted fluorescent ligand, that inhibits PRMT5 with an IC50 of 29.39 nM. PRMT5-targeted fluorescent ligand-1 exhibits cell imaging activity, that exhibits good fluorescence signal in MCF-7 with an IC50 of 29 nM. PRMT5-targeted fluorescent ligand-1 induces apoptosis. PRMT5-targeted fluorescent ligand-1 exhibits a maximal excitation wavelength of 438 nm and a maximal emission wavelength of 550 nm[1].

Molecular Weight

741.88

Formula

C43H47N7O5
SMILES

O=C1N(C2CCN(CC(N3CC(NC4=CC5=C(C=C4)CCN(C[C@@H](O)CN6CC7=C(C=CC=C7)CC6)C5=O)C3)=O)CC2)C(C8=CC=C(N)C9=CC=CC1=C89)=O
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Purity & Documentation
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PRMT5-targeted fluorescent ligand-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-targeted fluorescent ligand-1Fluorescent DyeHistone MethyltransferaseApoptosisMCF-7Inhibitorinhibitorinhibit

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