2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Proadrenomedullin (1-20), human

Proadrenomedullin (1-20), human  (Synonyms: ProAM N20, Human; PAMP-20, human)

Cat. No.: HY-P1831 Purity: 99.71%
SDS
COA
Handling Instructions Technical Support

Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells with an IC50 of ~350 nM for catecholamine secretion in PC12 pheochromocytoma cells, acting in a noncompetitive manner specifically at the nicotinic cholinergic receptor.

For research use only. We do not sell to patients.

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Proadrenomedullin (1-20), human Chemical Structure

Proadrenomedullin (1-20), human Chemical Structure

CAS No. : 150238-87-2

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Based on 1 publication(s) in Google Scholar

Proadrenomedullin (1-20), human Related Antibodies

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Description

Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells with an IC50 of ~350 nM for catecholamine secretion in PC12 pheochromocytoma cells, acting in a noncompetitive manner specifically at the nicotinic cholinergic receptor[1].

Molecular Weight

2460.84

Formula

C112H178N36O27
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2
Sequence Shortening

ARLDVASEFRKKWNKWALSR-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (40.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4064 mL 2.0318 mL 4.0637 mL
5 mM 0.0813 mL 0.4064 mL 0.8127 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.71%

SDS (252 KB)

COA (243 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4064 mL 2.0318 mL 4.0637 mL 10.1591 mL
5 mM 0.0813 mL 0.4064 mL 0.8127 mL 2.0318 mL
10 mM 0.0406 mL 0.2032 mL 0.4064 mL 1.0159 mL
15 mM 0.0271 mL 0.1355 mL 0.2709 mL 0.6773 mL
20 mM 0.0203 mL 0.1016 mL 0.2032 mL 0.5080 mL
25 mM 0.0163 mL 0.0813 mL 0.1625 mL 0.4064 mL
30 mM 0.0135 mL 0.0677 mL 0.1355 mL 0.3386 mL
40 mM 0.0102 mL 0.0508 mL 0.1016 mL 0.2540 mL
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Proadrenomedullin (1-20), human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proadrenomedullin (1-20), human150238-87-2ProAM N20, Human PAMP-20, humannAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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