1. Anti-infection Others
  2. Bacterial Fluorescent Dye
  3. Proflavine

Proflavine  (Synonyms: 3,6-Diaminoacridine)

Cat. No.: HY-B1741 Purity: 98.78%
SDS COA Handling Instructions

Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases.

For research use only. We do not sell to patients.

Proflavine Chemical Structure

Proflavine Chemical Structure

CAS No. : 92-62-6

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 70 In-stock
10 mg USD 110 In-stock
25 mg USD 220 In-stock
50 mg USD 355 In-stock
100 mg USD 560 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Proflavine:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
0.47 μM
Compound: Proflavine
Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
[PMID: 9371240]
A2780 IC50
0.47 μM
Compound: Acridine-3,6-diamine
Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells.
Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells.
[PMID: 7658436]
CHO IC50
0.52 μM
Compound: 1
Phototoxicity in transformed CHO cells after 24 hrs of UV irradiation by WST1 assay
Phototoxicity in transformed CHO cells after 24 hrs of UV irradiation by WST1 assay
[PMID: 19217190]
CHO IC50
1.1 μM
Compound: 1
Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay
Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay
[PMID: 19217190]
Keratinocyte IC50
> 50 μM
Compound: 1
Phototoxicity in normal human keratinocytes after 24 hrs incubation in dark by WST1 assay
Phototoxicity in normal human keratinocytes after 24 hrs incubation in dark by WST1 assay
[PMID: 19217190]
Keratinocyte IC50
> 50 μM
Compound: 1
Phototoxicity in normal human keratinocytes after 24 hrs of UV irradiation by WST1 assay
Phototoxicity in normal human keratinocytes after 24 hrs of UV irradiation by WST1 assay
[PMID: 19217190]
L1210 IC50
2.7 μM
Compound: Proflavine
Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
[PMID: 9371240]
L1210 IC50
2.7 μM
Compound: Acridine-3,6-diamine
Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells.
Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells.
[PMID: 7658436]
Clinical Trial
Molecular Weight

209.25

Formula

C13H11N3

CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (597.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7789 mL 23.8946 mL 47.7893 mL
5 mM 0.9558 mL 4.7789 mL 9.5579 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7789 mL 23.8946 mL 47.7893 mL 119.4732 mL
5 mM 0.9558 mL 4.7789 mL 9.5579 mL 23.8946 mL
10 mM 0.4779 mL 2.3895 mL 4.7789 mL 11.9473 mL
15 mM 0.3186 mL 1.5930 mL 3.1860 mL 7.9649 mL
20 mM 0.2389 mL 1.1947 mL 2.3895 mL 5.9737 mL
25 mM 0.1912 mL 0.9558 mL 1.9116 mL 4.7789 mL
30 mM 0.1593 mL 0.7965 mL 1.5930 mL 3.9824 mL
40 mM 0.1195 mL 0.5974 mL 1.1947 mL 2.9868 mL
50 mM 0.0956 mL 0.4779 mL 0.9558 mL 2.3895 mL
60 mM 0.0796 mL 0.3982 mL 0.7965 mL 1.9912 mL
80 mM 0.0597 mL 0.2987 mL 0.5974 mL 1.4934 mL
100 mM 0.0478 mL 0.2389 mL 0.4779 mL 1.1947 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Proflavine
Cat. No.:
HY-B1741
Quantity:
MCE Japan Authorized Agent: