2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Prolgolimab

Prolgolimab (BCD-100) is a human IgG1 anti-PD-1 monoclonal antibody containing the Fc-silencing 'LALA' mutation. Prolgolimab can be used for the research of advanced melanoma.

For research use only. We do not sell to patients.

CAS No. : 2093956-19-3

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Prolgolimab Related Antibodies

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Description

Prolgolimab (BCD-100) is a human IgG1 anti-PD-1 monoclonal antibody containing the Fc-silencing 'LALA' mutation. Prolgolimab can be used for the research of advanced melanoma[1].

Isotype

IgG1-Vlambda-Ckappa
Species

Human; Chimeric
IC50 & Target

PD-1[1]
In Vitro

Prolgolimab is an IgG1 anti-PD-1 mAb that contains the Fc-silencing LALA mutation, which provides an immunopotentiating advantage by abolishing the interaction between the Fcregion of the antibody and FcgR expressed on various immune cells, thus blocking the possible effector functions of the antibody[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Prolgolimab Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Prolgolimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-Vlambda-Ckappa
Purity & Documentation
References
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Prolgolimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prolgolimab2093956-19-3BCD-100BCD100BCD 100PD-1/PD-L1PD-1/Programmed death-ligand 1PD-1LALAadvanced melanomaInhibitorinhibitorinhibit

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