2. PROTAC
  3. PROTAC Linkers
  4. Propargyl-PEG4-sulfonic acid

Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-sulfonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG4-sulfonic acid Chemical Structure

Propargyl-PEG4-sulfonic acid Chemical Structure

CAS No. : 1817735-29-7

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Based on 1 publication(s) in Google Scholar

Propargyl-PEG4-sulfonic acid Related Antibodies

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Description

Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-sulfonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG4-sulfonic acid Related Antibodies
Molecular Weight

296.34

Formula

C11H20O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C#CCOCCOCCOCCOCCS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (168.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3745 mL 16.8725 mL 33.7450 mL
5 mM 0.6749 mL 3.3745 mL 6.7490 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3745 mL 16.8725 mL 33.7450 mL 84.3626 mL
5 mM 0.6749 mL 3.3745 mL 6.7490 mL 16.8725 mL
10 mM 0.3375 mL 1.6873 mL 3.3745 mL 8.4363 mL
15 mM 0.2250 mL 1.1248 mL 2.2497 mL 5.6242 mL
20 mM 0.1687 mL 0.8436 mL 1.6873 mL 4.2181 mL
25 mM 0.1350 mL 0.6749 mL 1.3498 mL 3.3745 mL
30 mM 0.1125 mL 0.5624 mL 1.1248 mL 2.8121 mL
40 mM 0.0844 mL 0.4218 mL 0.8436 mL 2.1091 mL
50 mM 0.0675 mL 0.3375 mL 0.6749 mL 1.6873 mL
60 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4060 mL
80 mM 0.0422 mL 0.2109 mL 0.4218 mL 1.0545 mL
100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.8436 mL
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Propargyl-PEG4-sulfonic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG4-sulfonic acid1817735-29-7PROTAC LinkersInhibitorinhibitorinhibit

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