Propiomazine hydrochloride 

Propiomazine hydrochloride is an orally active antihistamine agent with sedative effects. Propiomazine hydrochloride can be used in the research of insomnia^[1][2].

Propiomazine hydrochloride (0.2 mg/kg, nasal administration, rats) is quickly absorbed, followed by rapid reduction of the plasma concentrations^[3].
Propiomazine hydrochloride (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl₄-induced hepatic injury^[4].
Propiomazine hydrochloride (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

376.94

C₂₀H₂₅ClN₂OS

1240-15-9

CCC(C1=CC=C(SC2=C3C=CC=C2)C(N3CC(C)N(C)C)=C1)=O.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42.  [Content Brief]

  [2]. Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037.  [Content Brief]

  [3]. C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224.

  [4]. F T Serratoni, et al. Promethazine protection in carbon tetrachloride liver injury. An electron microscopic study. Arch Pathol. 1969 Jan;87(1):46-51.  [Content Brief]

  [5]. Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9.  [Content Brief]