Propiomazine-d₆ hydrochloride 

Propiomazine-d₆ (hydrochloride) is deuterium labeled Propiomazine (hydrochloride). Propiomazine hydrochloride is an orally active antihistamine agent with sedative effects. Propiomazine hydrochloride can be used in the research of insomnia^[1][2][3].

382.98

C₂₀H₁₉D₆ClN₂OS

1240-15-9

CCC(C(C=C1N2CC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])C)=CC=C1SC3=C2C=CC=C3)=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42.  [Content Brief]

  [3]. Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037.  [Content Brief]

  [4]. C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224.

  [5]. F T Serratoni, et al. Promethazine protection in carbon tetrachloride liver injury. An electron microscopic study. Arch Pathol. 1969 Jan;87(1):46-51.  [Content Brief]

  [6]. Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9.  [Content Brief]