2. PROTAC Epigenetics
  3. Epigenetic Reader Domain PROTACs
  4. PROTAC BRD4 Degrader-27

PROTAC BRD4 Degrader-27 is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3). PROTAC BRD4 Degrader-27 consists of E3 ubiquitinase ligand Thalidomide-4-OH (HY-103596), PROTAC Linker γ-Aminobutyric acid (HY-N0067) and PROTAC target protein ligand PROTAC BRD4 ligand-3 (HY-162876), of which the active control of the target protein ligand is Mivebresib (HY-100015), and the conjugate of E3 ubiquitin ligase ligand + Linker is Pomalidomide 4'-alkylC3-acid (HY-131875).

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PROTAC BRD4 Degrader-27 Chemical Structure

PROTAC BRD4 Degrader-27 Chemical Structure

CAS No. : 2407163-44-2

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PROTAC BRD4 Degrader-27 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC BRD4 Degrader-27 is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3). PROTAC BRD4 Degrader-27 consists of E3 ubiquitinase ligand Thalidomide-4-OH (HY-103596), PROTAC Linker γ-Aminobutyric acid (HY-N0067) and PROTAC target protein ligand PROTAC BRD4 ligand-3 (HY-162876), of which the active control of the target protein ligand is Mivebresib (HY-100015), and the conjugate of E3 ubiquitin ligase ligand + Linker is Pomalidomide 4'-alkylC3-acid (HY-131875)[1].

IC50 & Target

BRD4[1]
Molecular Weight

708.67

Formula

C37H30F2N6O7
CAS No.
SMILES

CN1C=C(C2=C(C1=O)NC=C2)C3=CC(NC(CCCNC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=CC=C3OC7=CC=C(C=C7F)F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PROTAC BRD4 Degrader-27 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRD4 Degrader-272407163-44-2Epigenetic Reader DomainPROTACsInhibitorinhibitorinhibit

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