PROTAC BRD9 Degrader-7

Cat. No.: HY-155361 Purity: 99.24%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

PROTAC BRD9 Degrader-7 is an orally active and selective degrader of BRD9 with a DC₅₀ of 1.02 nM. PROTAC BRD9 Degrader-7 has superior oral activity with a C_max of 3436.95 ng/mL.

For research use only. We do not sell to patients.

PROTAC BRD9 Degrader-7 Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC BRD9 Degrader-7 is an orally active and selective degrader of BRD9 with a DC₅₀ of 1.02 nM. PROTAC BRD9 Degrader-7 has superior oral activity with a C_max of 3436.95 ng/mL^[1].

Molecular Weight

649.69

Formula

C₃₆H₃₅N₅O₇

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N(C)C=C1C2=CC(OC)=C(CN3CCN(C4=CC=C5C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=C4)CC3)C(OC)=C2)C7=C1C=CC=C7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 70 mg/mL (107.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5392 mL	7.6960 mL	15.3920 mL
5 mM	0.3078 mL	1.5392 mL	3.0784 mL
10 mM	0.1539 mL	0.7696 mL	1.5392 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.29%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (246 KB) HNMR (408 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Jingyu Zhang, et al. Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia, European Journal of Medicinal Chemistry, Volume 262, 2023, 115872.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5392 mL	7.6960 mL	15.3920 mL	38.4799 mL
	5 mM	0.3078 mL	1.5392 mL	3.0784 mL	7.6960 mL
	10 mM	0.1539 mL	0.7696 mL	1.5392 mL	3.8480 mL
	15 mM	0.1026 mL	0.5131 mL	1.0261 mL	2.5653 mL
	20 mM	0.0770 mL	0.3848 mL	0.7696 mL	1.9240 mL
	25 mM	0.0616 mL	0.3078 mL	0.6157 mL	1.5392 mL
	30 mM	0.0513 mL	0.2565 mL	0.5131 mL	1.2827 mL
	40 mM	0.0385 mL	0.1924 mL	0.3848 mL	0.9620 mL
	50 mM	0.0308 mL	0.1539 mL	0.3078 mL	0.7696 mL
	60 mM	0.0257 mL	0.1283 mL	0.2565 mL	0.6413 mL
	80 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.4810 mL
	100 mM	0.0154 mL	0.0770 mL	0.1539 mL	0.3848 mL