PROTAC CDK9 degrader-4

Cat. No.: HY-115728 Purity: 98.38%: FAQs
Data Sheet SDS COA Handling Instructions

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PROTAC CDK9 degrader-4 is a highly potent and efficacious CDK9 degrader for targeting transcription regulation.

For research use only. We do not sell to patients.

PROTAC CDK9 degrader-4 Chemical Structure

CAS No. : 2411021-01-5

Size	Price	Stock
1 mg	USD 390	Ask For Quote & Lead Time
5 mg	USD 980	Ask For Quote & Lead Time
10 mg	USD 1550	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC CDK9 degrader-4 is a highly potent and efficacious CDK9 degrader for targeting transcription regulation.

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	13.6 μM Compound: 45	Growth inhibition of human BT-549 cells assessed as cell viability measured after 4 days by WST8 assay Growth inhibition of human BT-549 cells assessed as cell viability measured after 4 days by WST8 assay	[PMID: 34538051]
MDA-MB-231	IC₅₀	3.9 μM Compound: 45	Growth inhibition of human MDA-MB-231 cells assessed as cell viability measured after 4 days by WST8 assay Growth inhibition of human MDA-MB-231 cells assessed as cell viability measured after 4 days by WST8 assay	[PMID: 34538051]
MDA-MB-468	IC₅₀	15 μM Compound: 45	Growth inhibition of human MDA-MB-468 cells assessed as cell viability measured after 4 days by WST8 assay Growth inhibition of human MDA-MB-468 cells assessed as cell viability measured after 4 days by WST8 assay	[PMID: 34538051]

Molecular Weight

792.97

Formula

C₄₃H₅₆N₁₀O₅

CAS No.

2411021-01-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1CCN(CCCCCC2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)CC1)NC5=CC=C(CNC6=CC(N[C@H](CO)CC)=NC7=C(C(C)C)C=NN67)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (126.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2611 mL	6.3054 mL	12.6108 mL
5 mM	0.2522 mL	1.2611 mL	2.5222 mL
10 mM	0.1261 mL	0.6305 mL	1.2611 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.38%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (245 KB) HNMR (351 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14822-14847. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2611 mL	6.3054 mL	12.6108 mL	31.5270 mL
	5 mM	0.2522 mL	1.2611 mL	2.5222 mL	6.3054 mL
	10 mM	0.1261 mL	0.6305 mL	1.2611 mL	3.1527 mL
	15 mM	0.0841 mL	0.4204 mL	0.8407 mL	2.1018 mL
	20 mM	0.0631 mL	0.3153 mL	0.6305 mL	1.5764 mL
	25 mM	0.0504 mL	0.2522 mL	0.5044 mL	1.2611 mL
	30 mM	0.0420 mL	0.2102 mL	0.4204 mL	1.0509 mL
	40 mM	0.0315 mL	0.1576 mL	0.3153 mL	0.7882 mL
	50 mM	0.0252 mL	0.1261 mL	0.2522 mL	0.6305 mL
	60 mM	0.0210 mL	0.1051 mL	0.2102 mL	0.5255 mL
	80 mM	0.0158 mL	0.0788 mL	0.1576 mL	0.3941 mL
	100 mM	0.0126 mL	0.0631 mL	0.1261 mL	0.3153 mL