2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. PROTAC CDK9 degrader-5

PROTAC CDK9 degrader-5 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-5 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-5 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively.

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PROTAC CDK9 degrader-5 Chemical Structure

PROTAC CDK9 degrader-5 Chemical Structure

CAS No. : 2935587-89-4

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PROTAC CDK9 degrader-5 Related Antibodies

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Description

PROTAC CDK9 degrader-5 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-5 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-5 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively[1].

IC50 & Target[1]

CDK942

0.10 μM (DC50)

CDK955

0.14 μM (DC50)

In Vitro

PROTAC CDK9 degrader-5 (compound 15e) (1 μM; 6 h) decreases the protein level of MCL2, and competely degrades CDK9 in MV411 cells[1].
PROTAC CDK9 degrader-5 (1 μM; 1-6 h) time-dependently decreases the protein level of MCL2, and CDK9, and remaines suppression for 24 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC CDK9 degrader-5 Related Antibodies

Western Blot Analysis[1]

Cell Line: MV411 cells
Concentration: 1 μM
Incubation Time: 1 h, 2 h, 4 h, 6 h
Result: Degraded CDK9 starting at 2 h incubation and reaching a plateau at 4 h.
Remained suppressed for 24 h with some recurrence at 48 h after finished treatment.
Molecular Weight

879.78

Formula

C42H48Cl2N8O9
CAS No.
SMILES

O=C(NCCCCCCCCCCC(N1CCC(CC1)NC(C2=NNC=C2NC(C3=C(C=CC=C3Cl)Cl)=O)=O)=O)COC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC CDK9 degrader-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC CDK9 degrader-52935587-89-4PROTACsCDKCyclin dependent kinaseInhibitorinhibitorinhibit

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