2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Estrogen Receptor/ERR
  4. PROTAC ERα Degrader-10

PROTAC ERα Degrader-10 (Compound 160a) is an orally active degrader for ERα with DC50 of 0.37-1.1 nM, in cells MCF7, T47D and CAMA-1. PROTAC ERα Degrader-10 exhibits antitumor efficacy in mouse model. (Pink: ligand for target protein (HY-170339); Black: linker (HY-30105); Blue: ligand for E3 ligase Cereblon (HY-168055))

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PROTAC ERα Degrader-10 Chemical Structure

PROTAC ERα Degrader-10 Chemical Structure

CAS No. : 2421260-43-5

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PROTAC ERα Degrader-10 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

PROTAC ERα Degrader-10 (Compound 160a) is an orally active degrader for ERα with DC50 of 0.37-1.1 nM, in cells MCF7, T47D and CAMA-1. PROTAC ERα Degrader-10 exhibits antitumor efficacy in mouse model[1]. (Pink: ligand for target protein (HY-170339); Black: linker (HY-30105); Blue: ligand for E3 ligase Cereblon (HY-168055))

Molecular Weight

723.90

Formula

C45H49N5O4
CAS No.
SMILES

CC/C(C1=CC=CC=C1)=C(C2=CC=C(N3CCC(CN4CCN(C5=CC(CN([C@H]6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)CC3)C=C2)\C8=CC=C(O)C=C8
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC ERα Degrader-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC ERα Degrader-102421260-43-5PROTAC ERα Degrader10PROTAC ERα Degrader 10PROTACsEstrogen Receptor/ERRT47DMCF7BALB/c mouseCAMA-1orally activeInhibitorinhibitorinhibit

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