2. PROTAC Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. PROTACs CDK FLT3
  4. PROTAC FLT3/CDKs degrader-1

PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))

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PROTAC FLT3/CDKs degrader-1 Chemical Structure

PROTAC FLT3/CDKs degrader-1 Chemical Structure

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PROTAC FLT3/CDKs degrader-1 Related Antibodies

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Description

PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))[1]

IC50 & Target

CDK2

18.73 nM (DC50)

Molecular Weight

770.84

Formula

C40H42N12O5
SMILES

O=C(NC1=O)CCC1N(C2=O)C(C3=C2C=CC(N(CC4)CCC4CN(CC5)CCN5CC6=CC=C(NC(C7=NNC=C7NC8=C9C(NC=C9)=NC=N8)=O)C=C6)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC FLT3/CDKs degrader-1 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC FLT3/CDKs degrader-1PROTACsCDKFLT3Cyclin dependent kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3HL-60MV4-11THP-1KASUMI-1MOLM-13,NB-4OCI-AML-2acute myeloid leukemiaInhibitorinhibitorinhibit

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PROTAC FLT3/CDKs degrader-1
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HY-161708
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