2. PROTAC GPCR/G Protein
  3. Molecular Glues Prostaglandin Receptor
  4. PROTAC(H-PGDS)-7

PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC50 of 17.3 pM.

For research use only. We do not sell to patients.

PROTAC(H-PGDS)-7 Chemical Structure

PROTAC(H-PGDS)-7 Chemical Structure

CAS No. : 2761281-50-7

Size Price Stock Quantity
1 mg USD 160 In-stock
5 mg USD 350 In-stock
10 mg USD 560 In-stock
25 mg USD 1120 In-stock
50 mg USD 1800 In-stock
100 mg USD 2900 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

PROTAC(H-PGDS)-7 Related Antibodies

Top Publications Citing Use of Products

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DP EP FP IP TXA2/TP TXB2

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Description

PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC50 of 17.3 pM[1].

IC50 & Target

DP

 

In Vitro

PROTAC(H-PGDS)-7 shows potent suppression of prostaglandin D2 (PGD2) production in KU812 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC(H-PGDS)-7 Related Antibodies
Molecular Weight

742.78

Formula

C40H38N8O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1CCN(C2=CC=C(NC(C3=CN=C(OC4=CC=CC=C4)N=C3)=O)C=C2)CC1)N5CCN(C6=C(C(N(C7CCC(NC7=O)=O)C8=O)=O)C8=CC=C6)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (134.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3463 mL 6.7315 mL 13.4629 mL
5 mM 0.2693 mL 1.3463 mL 2.6926 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3463 mL 6.7315 mL 13.4629 mL 33.6573 mL
5 mM 0.2693 mL 1.3463 mL 2.6926 mL 6.7315 mL
10 mM 0.1346 mL 0.6731 mL 1.3463 mL 3.3657 mL
15 mM 0.0898 mL 0.4488 mL 0.8975 mL 2.2438 mL
20 mM 0.0673 mL 0.3366 mL 0.6731 mL 1.6829 mL
25 mM 0.0539 mL 0.2693 mL 0.5385 mL 1.3463 mL
30 mM 0.0449 mL 0.2244 mL 0.4488 mL 1.1219 mL
40 mM 0.0337 mL 0.1683 mL 0.3366 mL 0.8414 mL
50 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.6731 mL
60 mM 0.0224 mL 0.1122 mL 0.2244 mL 0.5610 mL
80 mM 0.0168 mL 0.0841 mL 0.1683 mL 0.4207 mL
100 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.3366 mL
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PROTAC(H-PGDS)-7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC(H-PGDS)-72761281-50-7Molecular GluesProstaglandin ReceptorDMDH-PGDSprostaglandincardiac hypertrophy,Inhibitorinhibitorinhibit

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Product Name:
PROTAC(H-PGDS)-7
Cat. No.:
HY-139972
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