2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs HDAC
  4. PROTAC HDAC6 degrader 4

PROTAC HDAC6 degrader 4 (Compound 17c) is the PROTAC degrader for HDAC6 with a DC50 of 14 nM. PROTAC HDAC6 degrader 4 exhibits inhibitory activit against HDAC1, HDAC2, HDAC3 and HDAC6 with IC50s of 2.2, 2.37, 0.61 and 0.295 μM, respectively. (Pink: ligand for target protein HDAC6 ligand-3 (HY-172360); Black: linker (HY-138387); Blue: ligand for cereblon E3 ligase (HY-W093272))

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PROTAC HDAC6 degrader 4 Chemical Structure

PROTAC HDAC6 degrader 4 Chemical Structure

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PROTAC HDAC6 degrader 4 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

PROTAC HDAC6 degrader 4 (Compound 17c) is the PROTAC degrader for HDAC6 with a DC50 of 14 nM. PROTAC HDAC6 degrader 4 exhibits inhibitory activit against HDAC1, HDAC2, HDAC3 and HDAC6 with IC50s of 2.2, 2.37, 0.61 and 0.295 μM, respectively[1]. (Pink: ligand for target protein HDAC6 ligand-3 (HY-172360); Black: linker (HY-138387); Blue: ligand for cereblon E3 ligase (HY-W093272))

IC50 & Target

HDAC6

14 nM (DC50)

HDAC6

0.295 μM (IC50)

HDAC3

0.611 μM (IC50)

HDAC1

2.2 μM (IC50)

HDAC2

2.37 μM (IC50)

Molecular Weight

767.81

Formula

C39H42FN9O7
SMILES

O=C(NCC1=CC=C(C(NNCC)=O)C=C1)C2=CC=C(OCC3=CN(CCCCCCNC4=CC5=C(C(N(C(CC6)C(NC6=O)=O)C5=O)=O)C=C4F)N=N3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC HDAC6 degrader 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC HDAC6 degrader 4PROTACsHDACHistone deacetylasesMM.1Smultiple myelomaInhibitorinhibitorinhibit

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PROTAC HDAC6 degrader 4
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HY-172359
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